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The Fertile Group Clinic Treatments

Fertility > Genetics

Preimplantation Genetic Test (PGT)

PGT is a valuable technique to prevent an eventual transmission of inherited genetic alterations. With this test, we ensure a healthy offspring, ending the transmission of the disease to future generations.

PGT is a valuable technique to prevent an eventual transmission of inherited genetic alterations.

What is the Preimplantation Genetic Test (PGT)?

The PGT, Preimplantation Genetic Test (former Preimplantation Genetic Diagnosis), is a consolidated technique that allows preventing the transmission of numerous genetic diseases from parents to children. It is performed within the framework of an in vitro fertilization cycle, and allows the detection of an affected embryo by some type of genetic disease before being transferred to the mother’s womb.

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In which cases is PGT indicated?

Both the PGT-M, for monogenic diseases detection, and the PGT-SR to detect structural alterations, are advanced techniques to detect an alteration or mutation of a specific gene (PGT-M) or a chromosomal structure alteration (PGT-SR), since in both cases these alterations would cause a disease to the future baby.

In order to transfer a healthy embryo and deliver a healthy baby, the PGT is indicated in several cases:

Couples

Couples with one of the two members are affected by a genetic disease inherited in a dominant manner (50% of their children can inherit the disease).

The mother is a carrier of a genetic disease

Couples in which the mother is a carrier of a genetic disease linked to sex (50% of her children could get it).

Both partners are carriers of a genetic disease

Couples in which both partners are carriers of a genetic disease inherited in a recessive manner (25% of their children would have the possibility to get sick).

Family history of a genetic disease.

Couples in which a member is a carrier of a structural chromosomal alteration.

PGT step by step

In any of the procedures of each one of PGT typologies (PGT-A, PGT-M, PGT-SR), the blastocyst biopsy process is the same.

On the other hand, the time needed to obtain the test results or specific couple analysis, are different in each case.

PGT-M

To detect possible monogenic diseases, we need a previous study to obtain all the necessary information. The duration of this phase varies according to the gene to be studied. Throughout the entire process, our specialists and the psychological support unit will always guide our patients with a close and personalized treatment.

PGT-SR:

To detect structural alterations in embryos or the presence of anomalous chromosomes due to the rupture or incorrect union of several segments, may be necessary specific studies prior to the biopsy process.

A consolidated technique that allows preventing the transmission of numerous genetic diseases from parents to children.

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